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Treatment resistant depression help.

Depression & Anxiety | Last Active: Dec 18, 2024 | Replies (28)

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@dlydailyhope

@melbourneaussie69
I noticed some benefit from both Wellbutrin/bupropion and Abilify/aripiprazole in about 2 weeks. Doctors in the states are starting to augment antidepressants with antipsychotics for those resistant to treatment and it may take a couple trials with the right mix and dosage. You shouldn’t need to wait more than 4 weeks to determine if a medication. The sooner you can tell if it helps or causes bad side effects, the sooner and easier weaning off should be. I tried fluoxetine (generic for Prozac) and I was okay 20 mg but when they increased to 40 mg, I started to get brain zaps so I started to wean myself off it.

I am so sorry for all you have experienced. You and your family have been through a lot and I pray that you get the best care possible within the socialized medical system. It must be hard to get timely, consistent, and quality care.

I don’t blame you for trying things on your own. I have often thought to myself that when someone is dealing with chronic pain and major depression that is hard to treat and they suffer for a long period, I wouldn’t be surprised that they would turn to anything they thought might help them endure each day. I am desperate for relief and it is hard to endure all of the medication and treatment trials but I keep having daily hope that something will work/help.

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Replies to "@melbourneaussie69 I noticed some benefit from both Wellbutrin/bupropion and Abilify/aripiprazole in about 2 weeks. Doctors in..."

Just a word of caution when supplementing antidepressants with antipsychotics. I found the combination to be very helpful with my treatment resistant depression. However I now have permanent Tardive Dyskinesia (weird uncontrolled mouth movements) from using Seroquel and Cymbalta with Wellbutrin. I’m 64 and have struggled with chronic severe migraines which exacerbated my depression and have tried just about everything to help with both conditions. I didn’t even know I had the weird mouth movements until I saw myself on a Zoom recording. I was horrified and immediately got off the antipsychotic but the TD never went away. I’m devastated over this permanent side effect. Be careful.