That's a good question: can the side-effects of the cure be more dangerous than the disease?

They've actually experiemented with this. For earlier-stage prostate cancer (PCa), ADT "holidays" once PSA is very low and stable produced similar or even slightly-better outcomes for many patients, possibly because the lowered risk of diabetes, heart disease, obesity, bone-mass loss, etc, outweighed any slightly-elevated risk of PCa progression. (They restart ADT if/when PSA rises again.)

However, for those of us with advanced PCa, it didn't work out so well. Going off ADT for "holidays" reduced overall survival noticeably, possibly because the dangers from progression are more immediate and severe.

In my case, there's the added risk that my stage 4 castrate-sensitive PCa might come back as castrate-resistant after an ADT holiday. Those are dice I will not roll.

Of course, a new study with new data might change best practices once again. Our field is moving fast.