Blood sugar levels and cancer cell growth
I listened to a podcast this morning, where “sugar” was discussed as an accelerator for cancer cell growth. Turns out, it does, but not for prostate cancer cells. However, the consequences of weight gain and blood sugar (NOT sugar per se) were identified as a much more important contributor to cell growth. If this is the case, why is ADT still dogma in support of treatment plans if one of the more obvious side effects of anti-testosterone hormonal therapy is weight gain? Do meds like ozempic offset some weight gain realities, and if so, are they deemed safe ?
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I was on ADT for eight years. Never gained any weight. Seems the problem is people get hungry and want to eat more, Easily resolved by not doing it.
I get on my scale every morning and based on what I weigh, I gauge what I can eat. A little self-control is all you need to keep your weight down.
You do need to exercise to beat off the fatigue from ADT. Some weight training to prevent your muscles from deteriorating as well as a lot of walking, At least 5000 steps a day. ADT will give you a belly, That’s because your stomach muscles deteriorate, Doing a lot of situps can offset that.
Sugar does add to prostate cancers growth. Sugar can be a risk factor for prostate cancer, and high blood sugar levels are associated with a higher risk of developing aggressive prostate cancer:
Thank you for your response. Perhaps I should have been more nuanced in my question. Going back to the example of sugar, when considering the growth of cancer is it more relevant to consider an individual's blood sugar levels than it is to consider the consumption of sugar. Having high blood sugar causes the body to produce hormones that feed cancer in a much more significant way than having the occasional doughnut, for example.
From my understanding, researchers are beginning to believe that adipose tissue (fat tissue) plays a role in increasing the aggressiveness of prostate cancer by releasing certain hormones, cytokines, and growth factors.
I asked the question to ascertain if this is all especially important to consider since weight gain is a common side effect of androgen deprivation therapy. Special emphasis needs to be placed on maintaining a healthy weight.
hanscasteels, somatic testing of the tumor yields information about the value of ADT for each individual. All prostate patients should consider Decipher or other testing for tumor mutations before taking ADT. Weight gain is more a consideration against ADT in patients who are obese and if they have more advanced cancer.
The effect of ADT on a tumor is dramatic. It can halve the size of the tumor within five months and quarter the PSA. Weigh gain is slower and with low carb diets are advised.
Clinical trial are why ADT is so commonly advised.
The consequence of weight gain is a much more improtant contributor to cell grow than sugar.
Drug interactions between Ozympic and ADT have not been found. There are other side effect with Ozymic alone that should be considered.
You may decide against ADT when you are clear about your own risks and advantages. It really is not a fun choice to to need to make. And you may decide to take ADT for several months before treatment and a month or so after. Bless your choice with luck.
Thank you. In my particular case, I also have to deal with the consequences of CABG. I want to ensure adequate and optimal treatment of this cancer monster, but not expire due to another issue that's enhanced by the treatment options. I suppose I am asking for the impossible - is it possible to defeat this cancer without ADT. Seems... "no" is the correct answer
@gently said “ Clinical trial are why ADT is so commonly advised.”
I’m wondering if you really meant to say this. ADT is advised for almost everybody who has prostate cancer that is advanced or has Recurred. Most people never even hear about clinical trials at that point.
I’m not sure where clinical trials are involved in ADT decisions.
Your thoughts!
When I went to my trainer to help me get into better shape for my surgery she started pushing the whole sugar thing so I told her I would investigate. It's was all based on an anti-sugar organization who did a 'study' that was proven to be false. Cancer was tested in heavy sugar saturation versus none at all and there was zero difference.
I’m not so sure your comments about sugar really are accurate. There are three different articles that seem to be saying the opposite.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6123266/
https://www.pcf.org/c/prostate-cancers-sweet-tooth/
https://pmc.ncbi.nlm.nih.gov/articles/PMC7811566/
hanscasteels, you might be interested in this https://www.nature.com/articles/s41391-024-00848-6. While prostate cancer specialists might not have the "bandwith" to address cardiovascular issues, do cadiologists have the bandwith to deal with the effects of ADT.
I suspect that it is possible to defeat prostate cancer without ADT, especially if it hasn't metastasized. But I think, or so I was told, that some tumors are not specially affected by ADT.
Oh wow - thank you so much.
This, then, poses more questions... If GnRH agonists used in prostate cancer treatment might increase heart risks, and if research suggests that GnRH antagonists could be safer for the heart, but evidence is limited, and practical challenges like costs and additional drug risks complicate their use... how do I, as a normal bloke, even make sense of this - especially since it appears to me that (at least in my care circle) they appear to gloss over and overlook managing these risks during treatment.
It stands to reason, then, that the focus should shift to identifying and addressing heart risks when receiving hormone therapy, using better tools and prevention strategies. (and what would they be?) GnRH antagonists may benefit high-risk patients like me, but how do I balance effective cancer treatment with managing side effects, including heart risks? How do I even start to address this with the oncologist, who I assume is not thinking in this direction. Maybe I should provide the prescription and take my chance?
Is it sugar ( as in the occasional donut) or blood sugar?