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Anyone have Prostate Cancer Stage 4 with good results?
Prostate Cancer | Last Active: Dec 22, 2024 | Replies (77)Comment receiving replies
At initiation of treatment in May 2024 my diagnosis was oligometastatic hormone sensitive prostatic cancer; GS (4+5)=9; iT3bN1M1A; NCCN Very high risk. As my current medical oncologist said, serious because it had metastasised to my pelvic region but not dire because it had metastasised to neither my bones nor my liver.
The Course of Treatment to date is:
Phase 1: 2024-04-25 to 2024-06-03: Eligard
Phase 2: 2024-06-04 to 2024-09-30: Eligard + Erleada
Phase 3: 2024-09-30 to 2024-10-25: Eligard + Erleada + Orgovyx
Phase 4: 2024-10-25 to 2024-11-17: Erleada + Orgovyx
Phase 5: 2024-11-18 to 2024-11-26: 5 Fractions of MRI Guided SBRT; Erleada + Orgovyx
Phase 6: 2024-11-27 to YYYY-MM-DD: Erleada + Orgovyx
The change from Eligard to Orgovyx was for logistical reasons since Orgovyx is a pill.
The effect of the hormone therapy on my PSA is as follows:
2023-08-21 17.5ng/mL
2023-09-25 18.5ng/mL
2024-03-28 37.3ng/mL (Three days before biopsy)
2024-04-28 ~40ng/mL (Day when initiated Eligard)
2024-05-17 25.0ng/mL (After 22 days of Eligard)
2024-06-28 2.01ng/mL
2024-08-26 0.39ng/mL
2024-09-10 0.19ng/mL
2024-10-10 0.14ng/mL
2024-11-11 0.09ng/mL
The decline in PSA along with a follow-up PSMA Ga68 PET/CT scan which showed the reduction or elimination of tumors in my pelvic region is most encouraging. By elimination I presume means reduction below the resolution of a PSMA scan if not complete elimination. Next labs will be in February since I presume the radiation precludes accurate labs for several months.
The hormone therapy has a minor effect on my quality-of-life. Perhaps a slight decrease in physical and mental energy at most. Not so for the five fractions of SBRT. Almost two weeks out and I little energy, mental or physical. In addition annoying urination/defecation issues, both predicted and both predicated to ameliorate in a few weeks. In the big picture trivial for staying alive.
I consider better than good results. First that I have prostate cancer and not a more lethal form of cancer. Esophageal cancer killed a boyhood friend within a year. Second that my prostate cancer became clinical when I was 82 years old and have lived a good life.
Replies to "At initiation of treatment in May 2024 my diagnosis was oligometastatic hormone sensitive prostatic cancer; GS..."
Let me add that even bone oligometastatic prostate cancer isn't as "dire" as it used to be, either. The new treatment options are impressive.
Hey rick, congratulations! You went thru a lot but came out better for it….one question I have: 5 fractions SBRT is usually associated with some form of CAT/MRI Cyberknife/Meridian treatment to the prostate gland.
But your cancer had spread to the pelvic region and even though the ADT shrunk those tumors to a size undetectable by PSMA, as you correctly point out - it doesn’t mean they are gone.
So why weren’t you given a more inclusive multi visit treatment with radiation that targets BOTH the gland and the pelvic region simultaneously - as in IGRT for salvage radiation?
I’m not an RO and probably displaying my ignorance here but did your doctor explain the ‘why’ to you? Just curious since I’ve met other men who’ve had similar cases and were given 25-39 lower dose treatments. Thanks!
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Hey old timer, your a great Secretary, I m impressed how you ve analyzed your predicament. Doing great for being in your 80s. No dementia in you: Mr. Einstein.