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Prolia and renal failure

Osteoporosis & Bone Health | Last Active: 6 days ago | Replies (16)

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@babby

I have taken 4 shots of Prolia and I have some bone growth improvement. I originally took one injection in 2012 and had severe muscle pain. I was told to stop taking it as I might be allergic. In 2022 a different PC told me I needed to start Prolia because my T- scores were not good on Dexa Bone Scan. I told her my history with Prolia experiencing muscle pain and told to stop in case it was an allergic reaction. She said the need outweighed the skepticism and I should start taking, which I did. I have fibromyalgia, severe scoliosis, spinal stenosis, spondylitis, collapsed L5 and Kyphosis. I took my 3rd injection in March of 2024. In June I was in so much pain I barely could go to store due to fear of falling because I was having trouble walking from pain. Again, doctor told me it could be fiber flares. I took injection in Sept of 24 and since first week in Nov I have been basically in so much pain I have been sitting at home in a chair in heating pads unable to go out unless there is a doctor appointment or grocery shopping, banking and chores. I demanded a MRI because I was afraid I had fracture, which I did not. I do have a very bad back. The doctor has told me to continue Prolia with two more shots. I actually missed Thanksgiving and stayed home in bed in so much pain in left leg. Bought a new bed for $4000 added a tempurpedic topper for $300 desperate to try to find some relief. None. I sit on 3 heating pads. Barely can shop. I clean a bathroom 1/2 at a time. I could go on. I sent money for Christmas gifts and canceled hosting dinner here for the first time in 50 years I’m in so much pain. It is getting a little better. My question is has anyone gone through this? I am dreading to have to take another injection in March and go through this horrid pain. Idk if it’s the Prolia, my back collapsing, or fiber myalgia. Has anyone had a reaction to Prolia?

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Replies to "I have taken 4 shots of Prolia and I have some bone growth improvement. I originally..."

@babby can you stop the Prolia and follow up with Reclast? It sounds like Prolia is not a good fit for you. Many of us have heard or read that the longer you take it, the worse the rebound loss in bone density when you stop, so maybe that is also a reason to stop. Reclast can help with the rebound. Of course discuss with your doctor. You can also get a second opinion.

If you have a "collapsed" vertebra that is a compression fracture, right? Are you seeing an endocrinologist? Perhaps Evenity would be an option. One study posted here by someone showed that Evenity could also manage rebound.

After Prolia I have been told that Forteo and Tymlos aren't effective but I am not sure if that is true in the future.