@autieoakley and @colleenyoung I respectfully offer another opinion based on what I have been continually told.

My doctor, chair of endo at a major teaching hospital, does not prescribe Prolia unless absolutely necessary. He jokes that he will prescribe it when retiring so he doesn't have to deal with rebound. (He was also concerned about effects on my wonky immune system.)

According to what my doctor said, if a person is old enough to take it for life, then it might be a good option, especially after anabolics. Lately McCormick ("Great Bones" ) has apparently been saying that 1-3 shots of Prolia might be okay but still need to be followed up with a bisphosphonate.

If it needs to be stopped, bisphosphonates, especially Reclast, are a necessity. So if the reason for Prolia is intolerance of bisphosphonates, that does not make sense, unless Prolia is never stopped.

Rebound loss of bone density and increase in fracture is a well-known phenomenon w/cessation of Prrolia. We are not posting about it because of bad personal experiences. I for one have been told again and again, and read, that Prolia rebound is very risky. I have never taken it as a result nor has it been offered by any of the endos I have seen.

Ben Leder MD talks about the potent effectiveness of Prolia in his videos on YouTube as well as increased potency of intersecting with Forteo. Very positive info. But he also says he no longer uses it much because of rebound.

I am glad some people are not suffering rebound, which is mysterious given the biology, but clearly some have exceptional experiences. My friend went off Prolia and seems to be okay but her DEXA was barely osteoporotic at one site. Maybe DEXA scores make a difference.

This might sound like strong opinion but it's not mine. It is my doctor's.