Only took the R ALA for a few days, but while taking regular ALA for several years, yes, it provided levels of relief for the peripheral neuropathy. Did not take it away totally, but did contribute to relief. Same for my husband, who is diabetic and has particularly serious PN in his feet. When whatever factors act up and intensifies his painful foot neuropathy, he applies Vicks, wears socks. THAT has helped him get through the really bad episodes. But he religiously takes daily ALA.