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@windyshores

Thank you @mayblin. This is very helpful and addresses my questions and validates @gently's speculation!

I liked the distinction between the acute phase reaction and longer term effects. I wonder why Benadryl is not also recommended-? I had no idea Claritin could be potent against inflammation. I had 5 days of substantial fever and a few more with lower fever after my infusion, which was low dose. I only used Tylenol.

I have systemic lupus (and very positive scleroderma antibodies) and was concerned about the possibility of a rise in inflammatory cytokines on Reclast. The article mentiones acute rise in cytokines but not chronic and doesn't suggest a cause for longer term pain.

I did Reclast June and Sept. of this year. I already had facial pain and numbness but noise triggers have become worse, the pain has become worse, and I have new jaw pain resembling TMJ. My rheumatologist responded that this could rarely be autoimmune inflammation.

Doctors all want me on steroids but I have afib and cannot do steroids. Perhaps Claritin will help me even now. I can only take Tylenol due to kidney issues. The pain and numbness are becoming a real issue, probably from my neck (stenosis, radiculopathy etc.) and I am not necessarily blaming Reclast at all- just covering my bases.

Again thanks @mayblin - and @gently!

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Replies to "Thank you @mayblin. This is very helpful and addresses my questions and validates @gently's speculation! I..."

Histamine is recognized as a potent inflammation mediator. To take an antihistamine like loratadine (Claritin) preemptively is a great way to guard against potential inflammatory processes elicited by bisphosphonate treatment. Studies are on going re anti-inflammatory activities of antihistamine drugs via other pathways.

First generation antihistamines such as diphenhydramine (Benadryl) is inferior for this purpose due to 1) shorter duration of action hence needing more frequent dosing 2) readily cross blood brain barrier resulting in undesirable sedating effects.