I switched from timed release ALA to the R-ALA. Everything was fine for about 6 days...then I experienced horrendous insomnia, as in suddenly wide awake, feeling pepped up, having to get out of bed. Horrible! This continued for about a week. I thought about "what's new" in my routine, medications, supplements...and it hit me that the only "new" factor was taking the R-Ala. Looked up info and found that indeed insomnia has been reported by users, along with a few other reactions. So I stopped taking it altogether. In addition, I took an additional tablet of cyclobenzeprine (1-mgs) which rheumatologist had OKAYED if I had increased fibromyalgic pain....I only took 10 mg b/c it would make me super groggy on following day. Anyway, I took 20 mg of the cyclo and NO ALA. On third night, managed to sleep 4 hours straight. Still not wonderful but sure beats only 1 to 2 hrs of sleep. I'll continue assessing and hoping that sleep gets restored to what I was used to (5 to sometimes 6 hrs)...meanwhile no R-ALA or regular ALA either.