Has anyone had to discontinue Zytiga due to side effects?

Posted by robertmizek @robertmizek, Dec 4 10:09am

I’m 7 months into an 18 month treatment with ORGOVYX and Zytiga. Everything has been manageable until the last few weeks when I started to experience significant dizziness and nausea. It became so bad this week that my MO is having be take a one week break and I still feel quite ill.

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shelby29 | @shelby29 | Dec 5 11:44am

I was on zytiga for 11 months, then had a heart attack, so I had to stop taking it.

melcanada | @melcanada | Dec 5 12:15pm

In reply to @jeffmarc "Parp inhibitors only work if you have BRCA1 or BRCA2 In your genetic tests. I say..." + (show)

Did the tests last year Took 2 months to get back Free NO HERIDARY PC thanks

robertmizek | @robertmizek | Dec 5 1:46pm

In reply to @shelby29 "I was on zytiga for 11 months, then had a heart attack, so I had to..." + (show)

Sorry to hear. I hope you’re doing better now.

shelby29 | @shelby29 | Dec 5 4:19pm

In reply to @robertmizek "Sorry to hear. I hope you’re doing better now." + (show)

Yes, had triple bypass....so good now! Still on eligard for another year. 3 years total due to Gleason 8.

robertmizek | @robertmizek | Dec 5 5:37pm

In reply to @shelby29 "Yes, had triple bypass....so good now! Still on eligard for another year. 3 years total due..." + (show)

Aside from the heart attack in the bypass I’m glad you’ve handled ADT well for two years. I was in athletic condition prior to surgery, radiation and ADT. I’ve been on ORGOVYX and Zytiga for a little over seven months now and the last month has kicked my ass.

shelby29 | @shelby29 | Dec 5 6:03pm

For sure not as strong as I used to be, but still lift weights 3 times a week and walk dogs everyday. My energy level is also good, but sleep is only so-so. I'm 73, 5'10 and 150#.

philnob | @philnob | Dec 6 6:50am

I was on Zytiga for several months when I noticed a shortness of breath. It started out in small increments, and within a week I felt like I was suffocating.
I called my nurse, and told her what was happening, and that I would no longer be using Zytiga. She told me she completely understood my decision.
I eventually moved on to Orgovyx, and Xtandi.
You’re not alone my friend. I wish you the very best in your options to deal with this problem.

Philnob

Inactive | @akiwi | Dec 6 11:52am

In reply to @melcanada "Appreciate Its said to stop Zytega just before it fails to get best benefit from Darolutamide???..." + (show)

"Its said to stop Zytega just before it fails" is it possible to tell this? @jeffmarc ?

jeffmarc | @jeffmarc | Dec 6 1:58pm

In reply to @akiwi ""Its said to stop Zytega just before it fails" is it possible to tell this? @jeffmarc..." + (show)

Not really. If you have gone two or three years Without it failing, then switching over is usually more successful. You know when it fails because your PSA rises