That l
ink was interesting @mayblin. I had breast cancer driven by estrogen; 80% of breast cancers are hormonal and 1 in 8 women get breast cancer. Most are older. I was interested in this:
Elevated Breast Cancer Risk Can Be Mitigated
With a therapy combining estrogen and progestogen, both estrogen plus progestin and estrogen plus progesterone were associated with a 10%-19% increased risk of breast cancer, but the authors say that risk can be mitigated using low doses of transdermal or vaginal estrogen plus progestin.
"In general, risk reductions appear to be greater with low rather than medium or high doses, vaginal or transdermal rather than oral preparations, and with E2 (estradiol) rather than conjugated estrogen," the authors writemayblin I was interested in this:
"In the WHI, 70% of the women were over the age of 65 when they initiated therapy, which partially accounts for the negative outcomes. In addition, in WHI, everyone was taking oral [HT].
and this:
Elevated Breast Cancer Risk Can Be Mitigated
With a therapy combining estrogen and progestogen, both estrogen plus progestin and estrogen plus progesterone were associated with a 10%-19% increased risk of breast cancer, but the authors say that risk can be mitigated using low doses of transdermal or vaginal estrogen plus progestin.
"In general, risk reductions appear to be greater with low rather than medium or high doses, vaginal or transdermal rather than oral preparations, and with E2 (estradiol) rather than conjugated estrogen," the authors write.
But I still cannot go near hormones with a previous cancer!! This should be reassuring for others.
Hi windy, thanks for bring this up. I think we are looking at the same link. I'd like to post the link here just in case anyone is interested in reading it. Many thanks to the original poster @gently :
https://journals.lww.com/menopausejournal/fulltext/2024/05000/use_of_menopausal_hormone_therapy_beyond_age_65.3.aspx
The authors provided extensive information in several tables as well as a statement of conclusiom. I actually brought a printout with me to discuss with my obgyn. Regarding breast cancer incidence tabulation, the % increase risk looked scary. However we need to know they are relative risk increase. The absolute increase in risk is roughly 0.1%. Interesting to note that mortality rate did not increase at all, probably due to early detection and treatablity. With the use of estradiol (bioidentical) with or without progesterone (bioidentical), topical route and appropriate dosing, the real risk increase is yet to be revealed with future well designed clinical studies. As for now, doctors tend to recommend against using hrt for those who have/had breast cancer, or a family history of breast cancer in general.