Even MORE reason to have Decipher! 3+3 Gleason is merely a starting point - no guarantees it stays this way as Gleason is based on observed numbers of dysplastic cells (and their degree of dysplasia) in a given area. If your Decipher comes back High Risk for metastasis then you can be assured of an increase in your Gleason over time.
My friend went from a 3+3 to a 4+3 in one year but luckily his Decipher score was low; he still needed treatment with those numbers and chose Cyberknife. He’s doing great.

@hirejohn
The 3+3=6 is usually a good number. When you get a 4 on either side and a 7 total is where treatments are recommended.

Not a urologist or R/O so just what I have read. But you state a family history of prostate cancer and that can definitely influence your medical providers to do more testing. The Decipher test will give the aggressive level to a low, intermediat or high.

I see you have been contacted by Colleen. I go to Mayo Jacksonville too. Have you met with a R/O. I was asked if wanted to do Decipher (it was explained what it was) and I said yes and it was done. They also did a bone scan and UFHPTI did a PSMA.
Good luck.

@hirejohn, Although you indicate you have a family history of prostate (and maybe especially so) you may want to consider getting a germline PCa genetic test, besides obtaining your Decipher Score.

You can get germline genetic testing for free by registering for the Promise study at the link below. Besides receiving the test results, you can speak with a genetic counselor who will explain them. https://www.prostatecancerpromise.org/about/

Also make sure you get a copy of your Decipher GRID report; which includes a lot of additional information (including a Clinical-Genomic Risk Model assessment), based on the PCa tumor cells taken from your biopsy.

Based on a mpMRI fusion biopsy, my 3+4=7 Gleason (with low volume pattern 4) was classified as "Low Risk" for metastasis, due to my 0.22 Decipher score. This along with the finding I had no genetic variants (mutations) for prostate cancer (based on my Promise study results) allowed me to confidently pursue active surveillance.

13 months after being diagnosed, and tripling my running program (upto ~35 miles/month) and losing 25 lbs, my 12 month follow-up mpMRI showed signs of lesion regression, as compared to my initial mpMRI and my post-biopsy PSA's have stabilized 20% below my pre-biopsy level.

I went to my urologist this morning and he indicates, based on all my data, I can delay another biopsy, since no sign of PCa progression is evident.

My vigorous exercise/modified diet approach has not been easy AND it's no guarantee to be successful for similarly diagnosed men; however, I like to share my story as an encouragement to those initially diagnosed with a similar situation as mine.

There is a viable alternative (I have not even discussed all the beneficial side-effects I've experienced) to immediate treatment, for men diagnosed with low risk PCa...but IMHO it requires implementation of a significant lifestyle change. Some men may not be able (or simply don't want) to adopt such changes...I understand...and to each their own.......

All the best with your results and decisions!