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Has anyone else had their chronic pain disappear while on Paxlovid?

Posted by thenazareneshul @thenazareneshul, Aug 20, 2024

So, I've got (diagnosed) Polymyalgia Rheumatica, in remission, and a whole host of other things. Like, CFS, right hip avascular necrosis, prominent epidural fat in multiple locations in my spine, just to name a few. But what's happened today takes the cake. Over 90% of my pain, which is chronic, has disappeared while I am on Paxlovid for having Covid. I've had to take the Paxlovid now for 3 days, I got on it early because my new "cold" moved quickly down into my lungs and I got seriously nauseous. That, doesn't happen for me, with colds, do we tested me (at home) for Covid, two times and both were positive. I currently have a good medical team, they called in the Paxlovid, and no other changes. I have good care at home, but 3 day in, almost all my pain is gone. Not that I'm complaining but I'd like to know what this might be. A pain management doc did do epidural steroid into L5 some weeks ago and it's true I've been slowing losing weight already, so that seems to be the first line of defense regarding dealing with epidural fat. I only learned about that a few days ago, and that sure gives me motive to lose more weight, but it's not like I have in just the last few days. Ideas? Meanwhile, I was taken off of all NSAIDs for CKD Stage 3 a month ago, so the pain went up, not down. What is the Paxlovid doing that makes my pain go away?

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heisenberg34 | @heisenberg34 | Dec 3, 2024
In reply to @fjp3709 "I have battled with CRPS, fibromyalgia, polymyalgia rheumatica, asthma and failed back syndrome for over 25..." + (show)
@fjp3709

I have battled with CRPS, fibromyalgia, polymyalgia rheumatica, asthma and failed back syndrome for over 25 years and the last 8 rheumatoid arthritis. Pain has been a constant companion until I got Covid in July and took Paxlovid. I was expecting to feel worse, but after 24 hours the Covid symptoms were 90% better but the pain was also gone and so was the incredible fatigue. By the 3rd day I was able to go for a brisk 5 mile walk. Although I had been on pain meds for many years I was able to get by on 1 pill a day broken in half.
This kept up till day 6, the day after I finished the Paxlovid. Now I’m back to square one.
I had 4 very nice days of energy and no real pain.
I hope someone is researching this!

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We’re you able to walk prior to taking the Paxlovid?

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1 reply
fjp3709 | @fjp3709 | Dec 3, 2024
In reply to @heisenberg34 "We’re you able to walk prior to taking the Paxlovid?" + (show)
@heisenberg34

We’re you able to walk prior to taking the Paxlovid?

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Yes. Had a lot of pain in shoulders and hips and back.
Disappeared about 12 hours after the first dose and stayed gone till about 12 hours after the last dose.

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1 reply
heisenberg34 | @heisenberg34 | Dec 3, 2024
In reply to @fjp3709 "Yes. Had a lot of pain in shoulders and hips and back. Disappeared about 12 hours..." + (show)
@fjp3709

Yes. Had a lot of pain in shoulders and hips and back.
Disappeared about 12 hours after the first dose and stayed gone till about 12 hours after the last dose.

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Interesting. Doesn’t seem like taking Paxlovid for the rest of your life is a viable option?

With the pain I’m in(8 most days), it would be tempting.

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1 reply
fjp3709 | @fjp3709 | Dec 4, 2024
In reply to @heisenberg34 "Interesting. Doesn’t seem like taking Paxlovid for the rest of your life is a viable option?..." + (show)
@heisenberg34

Interesting. Doesn’t seem like taking Paxlovid for the rest of your life is a viable option?

With the pain I’m in(8 most days), it would be tempting.

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I have read of some studies of giving Paxlovid up to 15 days for long COVID. Many of my pain symptoms and fatigue came after a bout of Epstein-Barr virus about 20 years ago.

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dboone | @dboone | Dec 21, 2024

I’m sorry for everyone’s different variations of pain here and all over the world. I agree that sometimes different things in our lives will take focus and take center stage from our chronic pain. Unfortunately, with me, being that I infused from L4 through S1 and the doctor paralyzed my left leg, it complicated other things of my body. Just depending on the day, one pain will take center stage from another pain, and because my leg is weak now if I fall that will take center stage so sometimes medication or what have you will take focus from one thing to another. May God bless everyone here and all those who have someone that takes care of them Until that day comes that the Lord either takes us home or it’s our time to go home when our pain will be gone.

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rayntyree01 | @rayntyree01 | 2 days ago
In reply to @thenazareneshul "This is my second time on Paxlovid, my second time getting Covid. My first time I..." + (show)
@thenazareneshul

This is my second time on Paxlovid, my second time getting Covid. My first time I was a lot sicker and I do remember the taste after taking the Paxlovid was truly terrible. This time it's not so bad. I think because I knew it was coming, I took it with food, like with my breakfast in the a.m. and a snack at the nighttime one. Also, this time I've had a lot more nausea, so I've been using some Odansetron sublingual tabs for that. It also seems to help.
Good luck. The truth is, it's still way better than a really bad course of Covid.

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Were you by chance taking meds for high cholesterol? If you were, and your doctor told you to stop taking it while you were taking paxlovid, that maybe the reason. Certain. Stain medications can cause chronic pain. Therefore, stopping that medication maybe the reason your pain has subsided. Also, it maybe due to the fact that your activity has no doubt declined. Sometimes, all you really needed was rest so your aching body can heal. Just my two cents…

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