Actually I was talking to sweet patient in a chair near me, so I lost track of the time. But I think between the actual medication and the saline it was 45 min to 1 hr. I know they were aware I had asked for a very slow drip. Maybe I didn't get it. This reaction is way stronger than what I have to a vaccine. Those never bothered me much at all. Looking at the hot tub outside and thinking, maybe that would help.