I was diagnosed with ILC, HR+/HEr2 low MBC, metastasis to bones, no mutations. My first line was Verzenio + anstrozole. I was on it for 18 months when I had further progression to bones. Verzenio did cause some diarrhea but nothing terrible. I didn't need to use anti-diarrhea meds except maybe a couple of times. Overall it wasn't too bad in terms of side effects. Anastrozole caused neuropathy in my fingers. I had received steroid shots to 2 of my fingers for trigger finger. They are still a bit stiff in the mornings but it gets fine as I move them.
After progression onco put me on Kisqali + Faslodex. Almost no side effects from Kisqali, except low WBCs. However, I think it never worked for me. My CA tumor markers started to increase a few months after I started Kisqali and kept rising. I was being followed up with CT and bone scans and twice they came back stable. My onco ignored the rising markers and after I pushed for a brain MRI it turned out there are 2 spots in the brain.