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Prescribed Tymlos after Evenity
Osteoporosis & Bone Health | Last Active: 4 hours ago | Replies (43)Comment receiving replies
This information is anecdotal, gleaned from doctors I've spoken with. That concern is probably influenced by the occurrence of osteosarcoma in female rats. Nonetheless, many doctors prefer to cycle off of anabolics in part to avoid this issue. Very simply put, the theory is that it's best to build bone, then focus on maintenance/antiresorptives , evaluate DXA and TBS and then consider re-introducing an anabolic. Since Evenity is so new, the protocols are not yet firmly established.
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But Evenity is not anabolic in the last 6 months, it is antiresorptive (less so than bisphosphonates).
@normahorn and @awfultruth my doctor agreed ( a few years ago) about Prolia'spotential effects on the immune system. It is one reason it was not prescribed (rebound being the other one). I have lupus and various allergies and generally have an unhealthy immune system so it was a concern.
People are focused on cardiovascular risks with Evenity but I read a study that said other issues needed research including the effect on B cell (acquired) immunity and bone marrow edema. Most don't have any problems on it but there may be a few who are vulnerable. Ditto side effects with other drugs.