Connect
← Return to Prescribed Tymlos after Evenity
Discussion
Prescribed Tymlos after Evenity
Osteoporosis & Bone Health | Last Active: 5 minutes ago | Replies (40)Comment receiving replies
@hollygs A couple of more points. First, your doctor who was alarmed at the Evenity followed by Tymlos situation wanted to switch you right away to Prolia, has a very different set of fears than I have.
I see your current sequence as unproven to be beneficial but definitely not proven to be harmful. Where as Prolia is proven to have two serious possibly life altering problems. Extremely rapid loss of bone after discontinuing Prolia and the potential for multiple fractures in addition to the bone loss.
Prolia is the one that scares me.
Also why immediately switch to another med. Why not find out if the Tymlos is working or not? That's the reasonable path in my opinion.
Second, you mention Fosamax and dental work. I just want to check whether you mean "invasive" dental work like tooth extractions and implants or above the gum line work like fillings and crowns etc. Bisphosphonates and Prolia are of concern with the invasive type but not crowns and fillings. You probably already know this but I wanted to mention it just in case. Good luck!
Replies to "@hollygs A couple of more points. First, your doctor who was alarmed at the Evenity followed..."
This is one of my fears with Polia (from drugs.com). My immune system is already on the deficient side.
"Yes, Prolia (denosumab) does appear to weaken your immune system. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including serious infections of the skin, abdominal, urinary tract, and ear. There is also a higher chance of developing endocarditis (an infection of the heart’s inner lining, usually involving the heart valves) in those who take Prolia, and those with advanced kidney disease have an increased risk of severe, life-threatening, low calcium levels (hypocalcemia) developing, particularly if they have a metabolic condition called chronic kidney disease-mineral bone disorder (CKD-MBD). For some side effects, people administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk.
Doctors may need to consider discontinuing Prolia in people who develop serious infections or other severe side effects."
Connect
@awfultruth Thank you for your reply. I agree with your points. I too have grave concerns in regards to Prolia. The concern in regards to Tymlos before or after Evenity is that you may start to produce abnormal bone. Tbh, the timing of introducing certain new medications seems to be lacking standard protocols and is up to the doctor's discretion. In my case, I'll do a DTX and TBS after I complete the first year of Tymlos. And in regards to Fosamax and dental work, that endo believes that you have to be off it for any dental work and that's unreasonable. Luckily, I have found a new metabolic bone specialist.