I am wondering how many of you out there have sensitivities, allergies and adverse reactions to many types of medications that are prescribed for chronic pain, like antidepressants, antiseizure, NSAIDs, antispasmodics and DMARDs. It seems like if you have any G.I. issues like gastritis, GERD, diverticulosis or IBS or Sjogren's, you are not going to do well with many of the medications prescribed to try to relieve the pain. It would be interesting and beneficial to know if this is a common problem among chronic pain patients so that we wouldn't face the doubt of prescribers that these sensitivities exist. IMHO - we really need a research study to investigate this.