Side effects of Letrozole: Weird muscle reaction

Posted by mjmac @mjmac, Nov 23 11:52am

Has anyone out had weird muscle reactions while on Letrozole. Ab area muscles in particular. I’ve had a CT of pelvic & Abdomen and they found nothing unusual.

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@jeanadair123

I just couldn’t handle it anymore.
One just hopes they made the right move but it was quality of life I put first.

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I had a second follow up with my surgeon. All was stable, mammo and MRI. I told her about all the physical symptoms and now blood work changing rapidly.
Told her my oncologist said chance of reoccurrence is 50/50, she explained that is the general population my age, my diagnosis etc. She said she would help find out more information. She called me later that day and said she presented my case to oncologists she works with at her hospital and they all thought my case would have a low % rate of reoccurrence.
With all factors considered, I stopped the Letrozole.
My oncologist probably won't be happy but I feel ok with this decision.

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@jeanadair123

They made me ache and feel like I was 100 years old I could barely get out of a chair. I tried 3 different ones all had the same side effects.

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Me too. Awful

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@flowergal

I had a second follow up with my surgeon. All was stable, mammo and MRI. I told her about all the physical symptoms and now blood work changing rapidly.
Told her my oncologist said chance of reoccurrence is 50/50, she explained that is the general population my age, my diagnosis etc. She said she would help find out more information. She called me later that day and said she presented my case to oncologists she works with at her hospital and they all thought my case would have a low % rate of reoccurrence.
With all factors considered, I stopped the Letrozole.
My oncologist probably won't be happy but I feel ok with this decision.

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My doctor figured out my chance was 14% stats are just stats. They told me my recurrence of vaginal cuff cancer was 1% it means nothing if you’re the one who gets it? There are so many people of this site with recurrence.

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@poodle

After only 2 weeks my eyesight was blurry. I was told by dry eyes and to stop talking Letrozole and everything would return to normal in a couple of days. That was 4 months ago and no better. Even after using prescribed eye drops every 2 hours. I used to be able to read a newspaper and do crosswords and suduko, now cannot read a paper or accurately get the numbers and letters in the squares of puzzles. Have new glasses but they don't work either. Head optometrist checked and prescription correct. I see ophthalmologist specialist next week and would like some information to present to him

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Although it has nothing to do with taking Letrozole, I had double vision and adding a prism to my prescription eliminated the problem. Just a shot in the barrel of false hope.

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Thanks Elisabeth but I don't have double vision.

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@flowergal

I had a second follow up with my surgeon. All was stable, mammo and MRI. I told her about all the physical symptoms and now blood work changing rapidly.
Told her my oncologist said chance of reoccurrence is 50/50, she explained that is the general population my age, my diagnosis etc. She said she would help find out more information. She called me later that day and said she presented my case to oncologists she works with at her hospital and they all thought my case would have a low % rate of reoccurrence.
With all factors considered, I stopped the Letrozole.
My oncologist probably won't be happy but I feel ok with this decision.

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After three visits back to my oncologist, I too stopped the Letrozole - on his watch until mid January and we'll reevaluate. My symptoms are debilitating - my hands are worthless, my whole body just hurts. Bones, muscles etc. I have no options for pain relief since I'm also on a blood thinner....

How long after stopping did you notice any improvement in how you feel? I'm very worried about the neuropathy in my hands being irreversible.

Hope you are improving.

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@jnorki

After three visits back to my oncologist, I too stopped the Letrozole - on his watch until mid January and we'll reevaluate. My symptoms are debilitating - my hands are worthless, my whole body just hurts. Bones, muscles etc. I have no options for pain relief since I'm also on a blood thinner....

How long after stopping did you notice any improvement in how you feel? I'm very worried about the neuropathy in my hands being irreversible.

Hope you are improving.

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I've only just stopped this past weekend. But prior to Letrozole I was on Anastrozole for about six months. I got off that and took a break of four weeks or so. It was about that last week my knees felt better and I could focus enough to read again. Read four books until the Letrozole kicked in.
So give it 4-5 weeks then document symptoms before you try the next AI.
I hope it goes better with the next one!
Happy Thanksgiving!

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