Have not had a long trip since diagnosis, but did have my sx increase before I knew what i had, first occurring after a long holiday car ride (6 hours) last December. I think it is important to get up and move while on long trips, even if walking down the plane aisle. I know that the trip that took me 6 hours last year is going to take longer this year because I am going to stop and walk the rest stops. And take Tylenol routinely during the day, even if I do not have increased pain prompting me. On 2 mg prednisone now with the hopes of decreasing in December but my sx will not allow that now, so continuing with 2 mg. Good luck.