Anyone stopped Orgovyx and started again if PSA rises?

In some cases, stopping and starting, the medicine can cause it to be less effective, but that’s usually with people who have much more serious cancer cases than you have.

I know many people who have stopped taking their drugs because their PSA dropped, as yours has, and some of them have gone a couple of years before their PSA started to rise. Stopping and starting a couple of times is not gonna really cause a problem.

This is something you should definitely consider doing. Make sure to get monthly PSA tests.

One of the benefits of Orgovyx is that the testosterone usually comes back quickly. That will make you feel better, be aware that at 78 testosterone tends to rise much slower than with the younger people.

90 days after RP with PSA "persistent" at .19 and a "clean" PSA pet scan, I was treated with Salvage Radiation to the whole pelvic region and pelvic lymph nodes as the most likely location for residual PCa, together with short term ADT.
My post Salvage Treatment PSA has been < .02 for about 1 yr now.
Very grateful for the results so far. Just sharing my treatment history.
Best wishes.

Hello All:I am 78 years old and had my prostate removed over 3 years ago. Post surgery my PSA was < 0.01. After two years it began to climb. At .93 a PMSA PET Scan was done finding no signs of cancer. The Mayo Clinic oncologist in Jacksonville put me on Orgovyx. I have been on it for over 7 months. I have had some weakness and hot flashes but nothing terrible which would alter my life style. After three months on the drug my PSA declined to .04. I go back to oncologist next week to take another PSA test. The doctor indicated I could go off Orgovyx (for awhile) if my PSA stayed low getting some of my testosterone back and I would feel stronger.My question to the group is, "Has anyone gone off Orgovyx and had to go back on because your PSA began to rise again?"

Hello All:I am 78 years old and had my prostate removed over 3 years ago. Post surgery my PSA was < 0.01. After two years it began to climb. At .93 a PMSA PET Scan was done finding no signs of cancer. The Mayo Clinic oncologist in Jacksonville put me on Orgovyx. I have been on it for over 7 months. I have had some weakness and hot flashes but nothing terrible which would alter my life style. After three months on the drug my PSA declined to .04. I go back to oncologist next week to take another PSA test. The doctor indicated I could go off Orgovyx (for awhile) if my PSA stayed low getting some of my testosterone back and I would feel stronger.My question to the group is, "Has anyone gone off Orgovyx and had to go back on because your PSA began to rise again?"

I know many people have that have done that. Some have stopped Orgovyx or Lupron, which works the same as Orgovyx, and a year, more or less, later, they have had to go back on it. it is possible you could be cured but a lot of it depends on your diagnosis.

I am surprised they didn’t do salvage radiation. Normally they do that after the prostatectomy when your PSA rises above .2. I guess the clear PSMA scan was why they didn’t do it.

What was your Gleason score after the surgery? Were there any other complications like intraductal or cribriform? if you had high Gleason, above seven, or the other two complications then it is very likely it will come back. The thing is no two people are the same so you can’t tell someone exactly what will happen to them.

Hello All:I am 78 years old and had my prostate removed over 3 years ago. Post surgery my PSA was < 0.01. After two years it began to climb. At .93 a PMSA PET Scan was done finding no signs of cancer. The Mayo Clinic oncologist in Jacksonville put me on Orgovyx. I have been on it for over 7 months. I have had some weakness and hot flashes but nothing terrible which would alter my life style. After three months on the drug my PSA declined to .04. I go back to oncologist next week to take another PSA test. The doctor indicated I could go off Orgovyx (for awhile) if my PSA stayed low getting some of my testosterone back and I would feel stronger.My question to the group is, "Has anyone gone off Orgovyx and had to go back on because your PSA began to rise again?"

Hello All:I am 78 years old and had my prostate removed over 3 years ago. Post surgery my PSA was < 0.01. After two years it began to climb. At .93 a PMSA PET Scan was done finding no signs of cancer. The Mayo Clinic oncologist in Jacksonville put me on Orgovyx. I have been on it for over 7 months. I have had some weakness and hot flashes but nothing terrible which would alter my life style. After three months on the drug my PSA declined to .04. I go back to oncologist next week to take another PSA test. The doctor indicated I could go off Orgovyx (for awhile) if my PSA stayed low getting some of my testosterone back and I would feel stronger.My question to the group is, "Has anyone gone off Orgovyx and had to go back on because your PSA began to rise again?"

Thanks for everyone's comments. Two points in order to address issues raised in previous responses; I cannot have radiation because I have a J-Pouch and radiation could damage the J-Pouch tissue. Additionally, I did not begin taking Orgovyx until after my PMSA PET Scan so there was no masking of any residual cancer. Finally my Gleason score was 9 and I probably should have expected some residual cancer even after my prostate was removed. At any rate the oncologist appointment is Wednesday and we will determine the future direction of treatments at that point. Thanks again to all who responded.

@rnpalarino1, I merged the 2 discussions together where you asked about restarting Orgovyx should your PSA indicate a rising trend.

May I ask, how did the appointment go with your oncologist? What did you learn? What did you decide to do at the moment?