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@windyshores

THanks @colleenyoung. @hollygs this article states that markers (all markers?) increase on Forteo and Tymlos. This is what I usually see. That other article that I posted above is the first time I have seen something more complex. Interesting that this article says bone markers are not useful when on anabolics since so many here on the forum are using them with Forteo and Tymlos to see if they are working, (I do have kidney disease so I don't use the CTX...) So confusing! Here is an excerpt:

"BTMs are not of much help in monitoring people on anabolic therapy. Anabolic therapies — such as teriparatide (Forteo), abaloparatide (Tymlos) and romosozumab (Evenity) — work by stimulating bone formation, which leads to increases in bone mass and density. Since new bone is being built, the markers are expected to increase and are not helpful in the decision-making process. There is also no role for monitoring after completion of anabolic treatment, as all these agents should be followed by treatment with anti-resorptive drugs without a pause in treatment."

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Replies to "THanks @colleenyoung. @hollygs this article states that markers (all markers?) increase on Forteo and Tymlos. This..."

@windyshores I agree, it is confusing! This is one of the reasons why medical professionals might bemoan patients using Dr Google. Ideally, our chosen specialist would be able and amenable to providing clarification about these seeming discrepancies as they apply to our individual case. At least one article I've read supported the use of monitoring BTMs as patients may have to wait for their DTX. There are also varying opinions about the optimal time to get a DTX, sometimes related specifically to the drug used and sometimes not. I don't understand how a doctor can decide on what sequence their patient will follow if they don't know what their response has been. Sometimes a protocol is established and followed to the letter, but sometimes it isn't. I think that this field is relatively new and ever-evolving. That may be exciting academically but challenging personally.