My experience with methotrexate was horrible nausea at first but I was able to taper prednisone easily from 7.5 mg, where I had been stuck, to 5 mg. Then it elevated my liver enzymes and stopped helping the PMR so I got off it. I was recently seen by a doctor in a pain clinic because back and leg pain is arising as Kevzara decreases the shoulder and hip PMR symptoms. He said that he has seen a number of PMR patients for similar problems and he observed that people try the DMARDs like methotrexate and the biologics like Kevzara and they either don't work or work for awhile, but in the end patients have to go back to prednisone because it works consistently and/or they had too many side effects on the other drugs.