@johnbishop I have always been pretty healthy, not getting sick much at all. I was diagnosed with cancer in 2012 and finished up my chemo and radiation in 2013. After about 6 months I noticed my left hand would go numb while I was driving and the left side of my upper thigh to my knee was numb. I went to a neurologist and she tested and said I had nerve damage but referred me back to my radiologist for medication. I took Gabapentin for 2 years but it didn't do anything to help me. In 2015 I went in for a small surgery on my right thumb and found out I had a left bundle branch block but no symptoms. The doctors said it was from my chemotherapy. My heart was only working about 25 percent. I had to have a pacemaker/defibrator. Now my numbness was on the bottom of my left foot. I felt like I was on walking on cotton balls. In 2019 I had a Pet Scan and they found a kidney stone lodged in the lower kidney at the opening of the bladder. They had to go in an get it instead of just busting it up. Tests showed my right kidney was doing almost nothing. Now my numbness was in the bottom of both feet and the last three toes on both feet. Usually I was just numb and didn't think much about it just tried to watch myself. One night I jumped out of bed and I felt like I was on fire in my upper left thigh. It shocked me how it hurt so bad I couldn't even touch it. Now it is tingling every day and working its way up my legs. I am 76. It has been a life changer for me. Can't run, get down on the floor to play with the grandkids and walk with a cane because it has affected my balance. I bought some reflexology shoes and they stop the numbness from going up my legs. I wear them 30 minutes every day or more. I am trying to walk everyday but can't walk as fast as I'd like. How long did it take to get some relief from numbness with the pills you are taking>