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Anyone have experience with immunotherapy clinical trials?
Hi- does anyone have any experience with immunotherapy clinical trials? Or more specifically the one sponsored by Janux Therapeutics? This would be for treatment for metastatic PC stage 4. 5FU was given post a distal Whipple (full removal of pancreas) in Dec 2022, followed by 5FU, then radiation and oral chemo, was said to be NED Nov 2023. Then 6 weeks later Feb 2024 cancer appeared in the perineum, so radiation was resumed and then in April Mets were seen in Liver and lungs. Since May has been on Gem/Nab Pacilitaxel and it was helping but now the cancer is showing resistance and new growth. So now before starting a 3rd line of chemo, considering this immunotherapy trial. There seems to be unknowns with both options- clinical trial or 3rd line of treatment. Struggling with what might be the best choice. Any thoughts or experiences are greatly appreciated! Thank you!
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There are several discussions about clinical trials in the Pancreatic Cancer support group. You might be interested in these:
- Anyone have any experience with clinical trials or immunotherapy?
https://connect.mayoclinic.org/discussion/clinical-trials-3/
- Looking for Clinical Trial for MRD (min. resid. disease) Immunotherapy
https://connect.mayoclinic.org/discussion/looking-for-clinical-trial-for-mrd-min-resid-disease-immunotherapy/
See all related discussions: https://connect.mayoclinic.org/group/pancreatic-cancer/?search=Clinical%20trials&index=discussions
@breemichelle26, do you have a link to the clinical trial by Janux Therapeutics to which you are referring? Have you talked with your care team about clinical trial options that you might be eligible for?
From my diagnosis in 8/2024 I have known the key to long term survival is training my immune system to find and attack this cancer. I am stage 3 locally advanced-borderline resectable.
I started an immunotherapy trial the same day I started Folfirinox.
I will have first post treatment CT soon. Ca 19.9 has dropped to 19 from 286 after 4 cycles.
I do think trials are worth the risks.
Good luck.
Regarding clinical trials, it is very important to know your gene mutations if you have one. This provides a better target for success. There are different types of therapies in trial. Immunotherapy, checkpoint inhibitors, etc.
The best trial for a person with BRCA 1or 2 is different than that for KRAS G12C. Or even for other KRAS variations. Call Pancan.org if you know your gene mutations and they can help you find trials that you could match with. For this disease, immunotherapy is not. Silver bullet just yet(at least for most of us). Medicine is moving faster-stay strong, keep fighting, and stay informed at each crossroads!
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4 ReactionsThank you very much for sharing! Are you able to share what Clinical Trial you are participating in? And do you know if/ what your tumor mutations are? Thank you again for sharing and wishing you continued success with your trial!