@mmusselman01, poppycock. Trials have restrictions to get solid, publishable results and set a baseline for future trials. That's why they typically look out for 3 years. Once they are more developed, they may look out for 5 years or more.

I'm still on Tagrisso after 4 years with no progression, and I have friends who have been on it for 7 and 8 years. I choose not to live my life by the odds but by hope, determination, and a sense of optimism.

Regarding nails, skin, and hair, I've increased my Biotin intake to 20 mg a day. As a result, my nails are stronger, my skin looks better, and my hair is growing like a weed! That's now my newest challenge, as I feel like I have to trim my nails every other day! My oncologist says that Biotin doesn't interact with anything I'm on (Tagrisso, Eliquis, prescription-strength Nexium, Fludrocortisone), but be sure to check with yours.