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Prescribed Tymlos after Evenity
Osteoporosis & Bone Health | Last Active: Nov 28 3:36am | Replies (43)Comment receiving replies
@hollygs,
Antisclerostin antibodies (Evenity) and abloparatide (Tymlos) can have an additive effect. Evenity blocks sclerostin. Tymlos depletes sclerostin using it to produce the cells that build bone. This unproven caution about is why you might not want to take Tymlos while Evenity is still active in your system. Evenity is thought to be gone from your system within 64 days after your last injection. So:
The unexamined question about Tymlos after Evenity no longer applies in your situation.
In my opinion you could be best served by continuing to take Tymlos for the remaining 4 months. Then I would want a second year of Tymlos.
I don't have experience with either medication.
Prolia and Fosamax can put your dental work at risk for osteonecrosis. Tymlos will protect your jaw bone and speed healing.
Your situation is actually ideal. You are safe now with the Tymlos and you have 4 months to find an endocrinologist who will prescribe a second year. Best wishes
Replies to "@hollygs, Antisclerostin antibodies (Evenity) and abloparatide (Tymlos) can have an additive effect. Evenity blocks sclerostin. Tymlos..."
@gently Thank you so much for your reply. After being fear-bombed by my new endocrinologist, I settled down over the weekend. I came to the same conclusion as you expressed here, and I really appreciate the succinct and gentle way you broke down your thought process for me. It makes sense to me, and I will calmly move forward with the original plan. It's so empowering to have your kind support and that of the others @mayblin and @windyshores who replied to me. I'm so very grateful. Best wishes to you as well.
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@gently I have never heard that Tymlos "depletes sclerostin." That is important information when thinking about a sequence either way. Can you share a source?
All I know about Tymlos is:
Tymlos (abaloparatide) is a man-made version of a protein related to the human parathyroid hormone (also called parathyrin). Parathyrin is important in bone remodeling where bone tissue is resorbed...
Since Evenity takes time to mineralize (my doc's words) my doctor said I could wait two months (but no longer) before starting Reclast. The same might be true for Tymlos.
We need more research quickly but with Evenity on the market only 5 years or so, it is going to take time. Initially doctors didn't even know that it's anabolic effect was short-lived.
I did Evenity for only 4 months. There are studies I have seen that test doing short bursts of Evenity between other drugs, and also doing Reclast at the 6 month point on Evenity because at that point Evenity, like Reclast, is anti-resorptive.
@hollygs I have not seen or heard of any increase in risk of osteosarcoma with a combination of Tymlos and Evenity, going in either direction. The risk with Tymlos and Forteo has not proven to be valid. Risk of osteosarcoma has not come up with Evenity, to my knowledge. So I am curious why a sequence of these would raise risk- regardless of which comes first.
As for osteonecrosis, Tymlos does not contribute to that since it is not anti-resorptive. Evenity is anti-resorptive for the last months but mildly so. So not sure where that concern comes from either. If you have heard this, I would love any information.