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Long term side effects of Evenity

Posted by polite @polite, Aug 31, 2023

My Bone Specialist Prescribed and My Insurance Co. approved Evenity. Would like more information on long term side effects and results; to help me decide on Evenity vs. Tymlos or Forteo. Many thanks in advance .
polite

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Mentor
Chris, Volunteer Mentor | @auntieoakley | 4 hours ago
In reply to @nanrox77 "My sister fractured her pelvis and was put on Evenity while recovering. She is 77 yrs..." + (show)
@nanrox77

My sister fractured her pelvis and was put on Evenity while recovering. She is 77 yrs old and never had any real medical problems. She has been on for over a year with a 6 month interruption due to insurance issues. Her primary care MD discovered last month that she has a rather loud heart murmur not present before. Echo shows mitral valve leakage. Cannot find if this could be related to the Evenity. Has appt with card MD soon.. Any ideas or info out there??

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Welcome to connect. I looked at a couple of places and couldn’t find valve disease in particular, but even its has a boxed warning about myocardial infarction and stated heart and vessel issues. Mostly it just says to let your doctor know if you have a history of heart disease.
Has your sister discontinued the evenity?

REPLY
gently | @gently | 25 minutes ago

nanrox77,
Uneven blood flow can create stress on the valve leaflets and the mitral annulus. Injury to the valves can become a site for calcium buildup. While atrial fibulation has been evidenced with Evenity, Evenity's disruption of flow causing valvular damage has not been established.
There is a study in mice which shows Evenity to be protect of the mitral valve.
Sclerostin which is found in the heart at sites of calcification was long thought to be moderate the progression of valvular disease. Evenity's mechanism of action reduces the presence of sclerostin.
There isn't evidence in the literature. And most of us earn leaky valves with age. My guess would be that the progression is related to Evenity.
It will be interesting to hear the cardiologist's thoughts. I hope that it's a minor leak, that the pelvis is healing and that your sister switches to Forteo.
Best wishes to you both.

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