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Transdermal HRT

Osteoporosis & Bone Health | Last Active: 5 hours ago | Replies (127)

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@hopefullibrarian

Hi mayblin, I'm happy to share. I've been on the 0.05 mg estradiol / 0.14 mg norethindrone acetate Combipatch since last March. My new gyno will start me off on the equivelant dosage of the estradiol patch (0.05 mg) and the oral prometrium (100 mg) then gradually increase the dosage. I have epilepsy, so we have to proceed with caution. She says it's easier to get the dosages where they need to be with these HRTs than it us with Combipatch. To be honest, I didn't ask why that's the case. I'm just happy to have a doctor willing to do it.

I don't have any articles or research to site on the combination of HRTs and bisphosphonates. I've chosen to do both so to counter Evenity rebound with the low dose Reclast infusion while increasing HRT dosage. I'll continue having my BTMs tested every 3 months to determine when to move on to Alendronate. The idea is to improve my bone metabolism while tapering off of osteomeds. I'm making decisions based on my knowledge of how the various treatments work and how my body is responding. So far so good!

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Replies to "Hi mayblin, I'm happy to share. I've been on the 0.05 mg estradiol / 0.14 mg..."

Thank you very much @hopefullibrarian for sharing your experience and thoughts on treatment planning. It's nice that you will switch to prometrium from a synthetic progestin, and adjusting estradiol dose will be a lot easier going forward. I wonder how your gyno will adjust your estradiol dose - will it be based on blood estradiol level, ctx results or symptoms of menopause if you still have them. I've read 0.05mg/day patch is commonly used. Please keep us posted.

Thank you for sharing, @hopefullibrarian This is such great information to have. Your Evenity results are astonishing. I have no data to support this, but I’m hopeful the combination of estradiol and Evenity will give me good results. Like you, I’m hoping to be able to taper off the osteoporosis meds at some point and rely on estradiol for a while. Given my age (52), my family history of living a long, long time, and the time limit on some of the meds, I’m looking at all options to manage this over the long haul. Again, thank you for sharing!