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Orgovyx

Posted by rnpalarino1 @rnpalarino1, 6 hours ago

Hello All:
I am 78 years old and had my prostate removed over 3 years ago. Post surgery my PSA was < 0.01. After two years it began to climb. At .93 a PMSA PET Scan was done finding no signs of cancer. The Mayo Clinic oncologist in Jacksonville put me on Orgovyx. I have been on it for over 7 months. I have had some weakness and hot flashes but nothing terrible which would alter my life style. After three months on the drug my PSA declined to .04. I go back to oncologist next week to take another PSA test. The doctor indicated I could go off Orgovyx (for awhile) if my PSA stayed low getting some of my testosterone back and I would feel stronger.
My question to the group is, "Has anyone gone off Orgovyx and had to go back on because your PSA began to rise again?"

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gently | @gently | 3 hours ago

Orgovyx can confuse the PSMA/PET. You might talk to the radiologist. I was told that this PSMA scan can be false negative if you are on Orgovyx.
Best wishes.

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jeffmarc | @jeffmarc | 2 hours ago

I know many people have that have done that. Some have stopped Orgovyx or Lupron, which works the same as Orgovyx, and a year, more or less, later, they have had to go back on it. it is possible you could be cured but a lot of it depends on your diagnosis.

I am surprised they didn’t do salvage radiation. Normally they do that after the prostatectomy when your PSA rises above .2. I guess the clear PSMA scan was why they didn’t do it.

What was your Gleason score after the surgery? Were there any other complications like intraductal or cribriform? if you had high Gleason, above seven, or the other two complications then it is very likely it will come back. The thing is no two people are the same so you can’t tell someone exactly what will happen to them.

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