1. < Prostate Cancer

PSE Test for Prostate Cancer Before an MRI and for Re-Occurrence

Posted by bens1 @bens1, Oct 22 8:31pm

I had a discussion with a SVP at Oxford Biodynamics last night about the accuracy of their PSE test for both potentially new prostate cancer patients and for those that get tested for biological re-occurrence. He basically explained, in layman’s terms, that regardless of having had treatment or not, the PSE tests 5 biomarkers will be accurate to show the likelihood or not, of prostate cancer 94% of the time.

He said that a change at the cellular level, because of new cancer cells, even when a psma pet scan will not pick up the micro cells, that their test will pick it up.

I have attached a chart he provided. Obviously part of his job is to spread the word, but I believe his intent to help was genuine. He also said that anybody that wished to email him to ask any questions to feel free to do so. His name is Steve Arrivo and his email address is: steven.arrivo@oxfordbiodynamics.com.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

episwitchpse | @episwitchpse | Nov 15 10:50am
In reply to @northoftheborder "As I understand it so far (and I might be wrong) "PSE" is a patented approach..." + (show)
@northoftheborder

As I understand it so far (and I might be wrong) "PSE" is a patented approach for combining a regular PSA test with a genetic test for risk markers, to reduce false positives and unnecessary biopsies during routine prostate-cancer screening of the broad population.

I already know I have prostate cancer, so I don't understand how looking for genetic risk markers with every blood test would add anything to the accuracy of my own PSA surveillance, but I might be missing something.

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Hi, thanks for your reply. Just to clarify, the EpiSwitch PSE test analyses immune cells in the blood that have been at interplay with prostate cancer (or not). Your PSA value only makes up a small portion of the results of the test. There are other very informative biomarkers assessing the presence or absence of PCa included in this test. So yes, EpiSwitch PSE can still be used with a very low PSA score, and can still detect prostate cancer without PSA shedding. Therefore, the test can be used before, after and during treatment - even after complete prostate resection. In your case, a 'low likelihood' result could potentially help you avoid things like PSMA scans if your PSA indeed rises over time. A 'high likelihood' result could be indicative of recurrence, irrespective of low PSA.

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northoftheborder | @northoftheborder | Nov 15 10:56am
In reply to @episwitchpse "Hi, thanks for your reply. Just to clarify, the EpiSwitch PSE test analyses immune cells in..." + (show)
@episwitchpse

Hi, thanks for your reply. Just to clarify, the EpiSwitch PSE test analyses immune cells in the blood that have been at interplay with prostate cancer (or not). Your PSA value only makes up a small portion of the results of the test. There are other very informative biomarkers assessing the presence or absence of PCa included in this test. So yes, EpiSwitch PSE can still be used with a very low PSA score, and can still detect prostate cancer without PSA shedding. Therefore, the test can be used before, after and during treatment - even after complete prostate resection. In your case, a 'low likelihood' result could potentially help you avoid things like PSMA scans if your PSA indeed rises over time. A 'high likelihood' result could be indicative of recurrence, irrespective of low PSA.

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Thank you for the reply. Just to verify, would the test have any added value with an undetectable PSA (< 0.01) while on Relugolix and Apalutamide? Or is it (as I think you wrote) something I'd use once my PSA started rising?

REPLY
episwitchpse | @episwitchpse | Nov 15 3:05pm
In reply to @northoftheborder "Thank you for the reply. Just to verify, would the test have any added value with..." + (show)
@northoftheborder

Thank you for the reply. Just to verify, would the test have any added value with an undetectable PSA (< 0.01) while on Relugolix and Apalutamide? Or is it (as I think you wrote) something I'd use once my PSA started rising?

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Hello. Thanks again for reaching out. I think PSE would still be useful as it can detect prostate cancer in patients with PSA (< 0.01), as PSA cannot detect cancer alone. The other biomarkers in the PSE test can detect the presence of PCa together. And yes, I do believe it would be prudent to order if PSA starts to rise. All the best.

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