I have been on a combination Prednisone/Actemra injection for over a year and have had no side effects that I am aware of. The Actemra will hopefully help me come off of the prednisone completely, though I am not there yet. I had tests done for GCA that came back negative, though I had all of the symptoms, including eye problems. So it made sense to treat for both PMR and GCA. Every day is a new something as I try to get myself off of prednisone.
Good luck. Hope it helps.
Therese