Thanks for responding...I am tolerating the injections quite well for almost two years now. Only side affect seems to be about 5 fingernails have deteriorated on the tips. I started taking Solary brand biotin daily and using Hansen nail hardener and that helps strengthen the nails. I am thankful I can still do many things with the help of pain meds. I am being treated in southwest Florida and have yet to meet anyone with MBC. Nice to know this site is available.