In the U.S., one in five people (20%) have the genetic allele, Lp(a). That's around 66.6 million people. There are 3 present drugs to treat Lp(a). There are 2 PCSK9 drugs Repatha and Praluent. Repatha can reduce LDL by 55%-75% and Lp(a) by 26.9%. Praluent can reduce LDL by 43-58% and Lp(a) by 26-30%. The 3rd drug an inclisiran drug, Leqvio reduces LDL by 40-60% and Lp(a) 20-30%. Does Ireland have access to these drugs? Pelacarsen, Ollpasiran, and Zerlasiran can reduce Lp(a) more effectively and may be available in 2-3 years.
Taking a high dose of statin does not decrease Lp(a) and can increase Lp(a) by up to 20%. Since Lp(a) is an independent factor no amount of exercise, diet or statin can reduce it.