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Questions about Prostate Screening EpiSwitch (PSE) testing

Prostate Cancer | Last Active: 1 day ago | Replies (15)

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@bens1

Guys: I just got my PSE test back to see if it showed biological re-occurrence. I have attached it without my personal info. When I asked about the 9 out 10 men and absence of cancer statistically, this is what they said:

"our Negative predictive value (NPV) is 95% - 95 out 100 are truly negative. The stats come from a study of over 400 men in a clinical study and the principal investigators, not the company."

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Replies to "Guys: I just got my PSE test back to see if it showed biological re-occurrence. I..."

northoftheborder | @northoftheborder | 1 day ago

Thanks for that. This helps confirm what I've been piecing together: from my understanding, the extra epigenetic test (the "E" in PSE) isn't useful if your PSA is normal/low/undetectable; however, if your PSA is high, adding the "E" can help you determine more accurately how much it matters.

So as long as my PSA remains < 0.01, PSE holds no value for me; but if it were to start climbing to (say) 10, the extra epigenetic test would help me know whether the cancer was spreading quickly yet and choose an appropriate treatment course.