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Most people quit their job under Big3?

MAC & Bronchiectasis | Last Active: 8 hours ago | Replies (27)

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@bayarea58

Rick, I have read prior posts of yours so understand you have cavitary disease. Were you then on daily Big 3? I have nodular bronchiectatic MAI with cavitation (C-NB) so daily Big 3 is being recommended to me with IV Amikacin for first three months. Wondering if you had similar protocol and what those side effects may have been like for you, acknowledging we are all different in terms of our responses to these drugs. I have read that daily Big 3 is much harder to tolerate than three days a week, so am curious about the experience of those that have done daily Big 3 and particularly with the added Amikacin IV.

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Replies to "Rick, I have read prior posts of yours so understand you have cavitary disease. Were you..."

All 3 daily for 28 months with Amikacin IV for 12 weeks and Arikayce at 18-23 months . A 6 month pause then AZ 3x per week with daily Ethambutol and daily rifampin. Yes, I do have a cavity 3x6 but it has scar tissue so it's permanent. I did not tolerate either amikacin or arikayce well at all.