Thank you for your feedback. I do not have any sensation of mucus, though my CT shows mucus impaction, so one’s sense of mucus and the need for airway clearance doesn't seem to directly correlate. I was recently diagnosed with an MAI infection (at same time as BE) and doing some more workup testing before I make a decision on the antibiotics. In the meantime, I want to get my ducks in a row on AC and environmental “hygiene”. I was curious if having an active infection was what supported 2x a day, as opposed to just daily hygiene with BE, regardless of mucus production. I am largely asymptomatic and produce very little sputum when I do airway clearance (with albuterol, vest, breathing techniques, Aerobika). But was thinking 2x daily might improve the anti microbial impact of the 7% saline. Just not sure if there is any science to support my thinking or if more than once a day is unnecessary. It is a lot of time to do 2x a day but hopefully I will get more efficient with AC all over time.