Hi gema98. Are you using estrogen cream in additional to Clobetasol cream? I was alternating these two topical meds until a few weeks ago. The GU/GYN doc said to use the estrace cream every night. It has helped a lot but I'm wondering if there is a cancer risk. Hope I can get some answers soon. I'm not worried about the Mohs just the local anesthesia. I've had numerous Mohs surgeries and that is the worse part as there is no feeling during the surgery. I'm not familiar with PBC. Is that what contributed to the liver cirrhosis? So sorry you're having to deal with that.