Yes, PSE can be used to detect recurrent prostate cancer. Like one of the commenters mentioned above, the test analyzes immune cells in the blood that have been at interplay with prostate cancer (or not). The National Comprehensive Cancer Network (NCCN) guidelines urge provider to utilize tests (biomarkers) that enhance the specificity of results. PSE has 97% specificity compared to PSA's 53%. So I do think PSE can serve as a superior early detection tool that may also help avoid unnecessary MRIs and/or biopsies due to high PSA scores that aren't actually a reflection of disease recurrence.