Lesiel,
We took your questions to a Mayo Clinic pharmacist. She replied with this response:

"Hopefully if your dose of prednisone continues to decrease it will help those afternoon blood sugars come down as well. Stopping any of your doses of metformin probably won’t change those afternoon blood sugars too much either. Metformin helps the insulin in your body to work better, but doesn’t tend to drop blood sugars quickly. Increasing your midday glipizide may help to decrease those afternoon sugars, but glipizide can also cause low blood sugar, so increasing that dose would need to be done carefully. Unfortunately, it is often a guessing game to figure out how to individualize medications to control those sugars. As your prednisone dose changes, you’ll probably continue to change those blood sugar medications. Continue to discuss this with your healthcare providers and make your suggestions!"

Lesiel, it sounds like continued conversation with your doctors and diabetes educators is of vital importance. I hope this answer gives you some ideas to bring back to them. When is your next appointment?

I'd also like to bring others into this conversation. Please join us @iman_im @panicek @ggibault @cowen150 @rlmac27