@beebe I would strongly recommend hysteroscopy with D&C by a gyne onco rather than just a regular gyne or pcp. The gyne onco will be able to give you more accurate info and more likely to biopsy the areas correctly in the uterus. I had done some research on accuracy of endometrial biopsies, pelvic us, etc since I was deciding on BSO vs TAH/BSO and I found out that overall you will get the best care for potential gyn cancer by going to gyne onco even for the initial testing. Also - hysterscopy with D&C for the endometrial biopsy is more accurate than in office endometrial biopsy. While in office is 'easier' b/c you don't need to be sedated, the doctor has to do it 'blind' so they're just guessing and of course that limits accuracy. With the D&C approach they can visualize and take additional samples as needed if they see other areas of concern. They also take out polyps and anything else that shouldn't be there, whether its benign or not. Idk if the vag estrogen alone could thicken the lining but whether to continue that is another good question for a gyne onco. I'm on aromatase inhibitor for BC but was told by the gyne onco that since it blocks all estrogen that significantly lowers my risk for uterine cancer. If you don't "need" to take the vag estriol, you can just stop it for now in case there is any estrogen responsive (pre)cancer cells growing until you find out more info. Best of luck to you, hope you get your tests soon and that you get all good news.