1. < Neuropathy

Vitamin B6: pyridoxine hydrochloride vs. pyridoxal 5’-phosphate?

Posted by Ray Kemble @ray666, Sep 14, 2023

I had posted this earlier in the midst of a longish thread. As I've not had any responses, I thought I might post it as a topic all its own:

Good morning. Maybe someone following these posts about B6 can help me sort something out. I understand vitamin B6 is available as pyridoxine hydrochloride in multivitamins, vitamin B-complex, and vitamin B6 supplements. My neurologist tells me that pyridoxine hydrochloride in the form of vitamin B6, if taken in excess, can lead to toxicity with its various PN-like symptoms. He assures me, however, that the form of vitamin B6 that I’m taking in EB-N5, which is pyridoxal 5’-phosphate, is essentially different; pyridoxal 5’-phosphate comes with its own dosage guardrails, but not the same toxicity concerns that accompany pyridoxine hydrochloride. Have you met this “two forms of supplemental B6” issue in anything you’ve read or been told? I have found brief mention of it in only a few places. I’d love to get some clarity. –Ray (@ray666)

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Mentor
John, Volunteer Mentor | @johnbishop | 5 days ago
In reply to @bluestarborn88 "Hi Ray, You might have already found more info on that. Just in case : The..." + (show)
@bluestarborn88

Hi Ray,

You might have already found more info on that.
Just in case : The pyridoxine hydrochloride is the Synthetic Vitamin B6.Synthetic Vitamin B6 – Pyridoxine hydrochloride comes from petroleum ester, hydrochloric acid, and formaldehyde. It isn’t readily absorbed or converted and has been shown to actually inhibit the action of natural B6 in the body. It also has side effects not normally found with natural food sources of this vitamin. It has been found that long-term use of high doses of synthetic Vitamin B6 can cause neurological problems such as tingling and numbness in the hands and feet due to nerve damage caused by an accumulation of unmetabolized molecules from supplements.

Natural sources of vitamin B6 is Pyridoxal 5 phosphate, it's the active form of vitamin B6 refer primarily to food products derived from animal or plant sources which contain active concentrations of this micronutrient including poultry, beef liver, eggs, bananas, avocados and potatoes, red bell pepper (raw), pasilla peppers (dried - from Mexico), leafy greens like spinach and kale, dried shiitake mushrooms, chickpeas, sunflower seeds, pistachio nut.
Foods High In Vitamin B6

Natural forms of vitamin B6 are more likely to retain its bioactive components since they haven’t undergone any chemical processing prior to ingestion.

Dr. Janine talks about whole food vs synthetic vitamins looking specifically at Vitamin B6.

As a new member they didn't let me provide some links that I wanted to post. Might repost this in a few days or so.

Jump to this post

Welcome @bluestarborn88, I thought I would share the link for you since new members are not allowed to share links for a short period of time to prevent spammers on Connect.

Whole Food vs Synthetic Vitamins | Vitamin B6 | Dr. J9 Live: https://www.youtube.com/watch?v=JpdWYa-VNsE

Also one of her other videos mentioned this reference:
-- Vitamin B-6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8483950/
Do you have neuropathy also?

REPLY
1 reply
bluestarborn88 | @bluestarborn88 | 5 days ago
In reply to @johnbishop "Welcome @bluestarborn88, I thought I would share the link for you since new members are not..." + (show)
@johnbishop

Welcome @bluestarborn88, I thought I would share the link for you since new members are not allowed to share links for a short period of time to prevent spammers on Connect.

Whole Food vs Synthetic Vitamins | Vitamin B6 | Dr. J9 Live: https://www.youtube.com/watch?v=JpdWYa-VNsE

Also one of her other videos mentioned this reference:
-- Vitamin B-6-Induced Neuropathy: Exploring the Mechanisms of Pyridoxine Toxicity:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8483950/
Do you have neuropathy also?

Jump to this post

Hi John,
Thank you so much for sharing the links!
I don't have neuropathy, but have other minor health issues.

REPLY
rollgal | @rollgal | 5 days ago

Hello, I have notes I made when researching "critical nutrients for nerve repair" in which I noted this recommendation:
B6 - Pyridoxal-5-Phosphate - 80-100 mg (the active form of vitamin B₆, is a coenzyme in a variety of enzymatic reactions). I believe it was from a doctor online. He said the more expensive forms of the B vitamins were more effective than the cheaper versions usually used in inexpensive multi-vitamins. Hope this helps.

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