Are you sure you do not have Pseudo in your lungs also? If you have BE and MAC then good chance you do?? My pulmonary specialist says that Pseudo usually goes up to the sinus also. I have it throughout my pulmonary system. Cipro vs Levo is very similar treatment. Some studies say Levo is more effective but i think most say Cipro is. But make sure you are aware of the side effects of each which can be very bad for some people. And I would at least check in with my Pulmo who would probably ok the Cipro 500. You can nebulize with a mask instead of the mouthpiece and maybe that would help with your sinus infection some.