It is unlikely that Darolutamide will work if Enzalutamide (xtandi) stopped working. You could try it, ask your oncologist

If you have not been on Zytiga that may be a better choice. It is usually used before one of the lutamides but it probably would work after. Ask your Oncologist.

Another option would be to try BAT? This is where you Get testosterone injections for a few months and it hopefully resets your ability to have a drug like Xtandi work again. Doesn’t work with everyone.