Hello @weten2, Welcome to Connect. You will notice that we moved your post to an existing discussion on the same topic so that you can connect with other members who are new to a PMR diagnosis. If you click the link below it will take you to the beginning of the discussion and you can learn what has been shared by other members and what questions they have mentioned.

-- NEW to PMR diagnosis: https://connect.mayoclinic.org/discussion/new-to-pmr-diagnosis/

That is definitely a difficult decision to make. I've had a TKR on my right knee but it was after my PMR had been in remission for a couple of years. If it were me, I would have a discussion with the surgeon doing the TKR to get their thoughts. I don't think you can be on prednisone and have the surgery and there are a lot of pre-surgery leg exercises that my surgeon had me doing prior to having the TKR. Have you talked with the surgeon?