Just attended a UCSF webinar about Gleason and cribriform issues. If you have large cribriform (over .25mm) that means your cancer is very aggressive even if you only have a Gleason 3+4. Chance of Metastasis with large cribriform is very high. You need to find out if your cribriform is large.

They mentioned that intraductal cannot be determined. You want them to determine that because if it is there, it means that you have large cribriform or at least the equivalent high risk. They also say that your biopsy slides should be reviewed by a Genito urinary pathologist, they know better what to look for.

Here is a graph which shows some of what’s going on.