I've had little to no side effects from the methotrexate, frankly I can't think of any problems that I can attribute to that drug. I do take 2.5 mg x 6 tablets just one day per week, taking 3 x 2.5 mg when I get up and the remaining 3 x 2.5 mg around 3:00 pm. I can't say for sure if it is working but I do experience less stiffness and pain and have reduced prednisone from 20 mg / day to 2.5 mg/day. So although I'm not pain free I am pretty much functional - gym 6 days / week and lots of yard work, etc...There was a time not long ago that I needed a shoehorn to put my shoes on - that is gone and my hamstrings and calf muscles killed me that is gone too. Hope this helps and hope methotrexate works for you.