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Starting immunotherapy Keytruda

Lung Cancer | Last Active: 11 hours ago | Replies (26)

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@sglaza

Hello burdyblue,
FYI, I was also scheduled for 4 rounds of chemotherapy however the kidney toxicity issues cropped up and my oncologist decided that the 4th round would only cause additional kidney problems. Make sure they are paying close attention to your BUN and eGFR blood values prior to each treatment to make sure they are not getting too elevated.
Good luck on the rest of your infusion treatments and then, presumably, your oral treatments with Tagrisso.

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Replies to "Hello burdyblue, FYI, I was also scheduled for 4 rounds of chemotherapy however the kidney toxicity..."

Thank you, sglaza.
Oh, I see about the the 3 rounds only. The first round for me with cisplatin and pemetrexed, (coupled with Ativan to alleviate anxiety which was a godsend, the 6 hours drip time passed in a haze) was brutal. I was "okay" day 1-3 with flu like feeling no great nausea or vomiting, the acute phase. But the delayed phase from day 4 was treacherous. I thought side effects would not continue with the supposed wash out of the chemicals after 2 to 3 days. Not so. Got thrush in my mouth, my throat swelled and I lost my voice, rash like mosquito bites all over my shoulders, chest, back, head. Terrible nausea and vomiting broke through on day 4 and it took 8 hours to get that under control and then I was on protein liquids only for nearly 5 days and lost 5 lbs, felt wobbly and my gait was off, floaters in my eyes, ringing in my ears, moody and weepy, felt like my limbs were encased in buckets of concrete with fatigue that set in. I was no sooner feeling better by day 14 then it was 5 days to countdown for treatment #2. I called the oncologist to switch to carboplatin, an alternative that supposedly doesn't do kidney damage with less nausea effects, so I read on the Internet, by way but I don't know. She advised me to meet her halfway and she would reduce the drugs instead, to hang in there with the cisplatin she thought was the better choice so I compromised. I am on day 3 out from round 2, and okay, so I will let you know how the rest fares. . It does feel like it is not so bad this time. I never wanted this chemo, but I was on the fence between stage 1 and 2 and accepted it for "insurance." I will look into Tagrisso, thank you for that info. My biomarkers state that I am not a good candidate for immunotherapy if that is what it is. But the oncologist says I still might want to do immunotherapy for a year because it just might help. I don't know about much of that at this point in my treatment yet. I did ask about my BUN and eGFR values after the first treatment and they were good to go. Thank you for that advice. I was afraid of long term effects I learned as I researched too about hearing loss, nerve damage and so on, so I said no to the chemo at first. So, I sat with the uncomfortable prospects for days until it came to me that as long as I can move my hand to write and paint, my quality of life would be acceptable if I lost some hearing and my nerves were damaged, but supposedly should come back at a pathetically slow rate as in years, especially with exercise and strength training. That is the hardest thing to do--in South Texas it is finally cooling off and to will myself off the couch takes a tremendous amount of self parenting myself! Thank you for your response. Made my day when I finally got to the computer here for support. I'm sorry if I overshared too many of the side effects, don't want to be negative, but it was brutal but it was doable. My spouse was there and my oncologist responded with all sorts of quick fixes for the thrush and so on. And yay for those who handled the side effects better than me. I'm not the young, fit chick I used to be! Again, many thanks for responding. __Burdyblue