While on Zytiga my blood pressure increased so much I ended up on three different pills twice a day. Before.Zytiga I never had blood pressure problems. Since getting on Darolutamide I’ve been able to reduce the amount of blood pressure medication I’m taking and my blood pressure has gone down a lot. Around 105/65 most days vs 125-130’s and up with Zytiga.

Darolutamide does not get past the blood-brain, as a result, my brain fog has reduced a little bit. Being on Lupron/Orgovyx also causes that fog however.

There was a conflict between Zytiga And Prilosec, Darolutamide does not have that conflict.

According to other people that have been on both drugs, there is much less fatigue with Darolutamide. That’s not one of the problems I’ve had with either drug.

While on Zytiga for 2 1/2 years, my PSA was only undetectable one month, it bounced all over as high as 2.2 but usually below .7. Four months after starting Darolutamide my PSA dropped to undetectable and has stayed that way for 11 months.

I had skipped beats frequently on Zytiga, very infrequent on Darolutamide.

I had 3 afib events on Zytiga.