Thank you for you input. Having my 5th dose gem/doc tomorrow with one to go after that. Scheduled for a cystoscopy end December to see inside if it worked. Good to hear your good news. Hope it continues to work for us both. Take care.

@deb2024, was this your first treatment method, or did this follow BCG? I’m also high grade non invasive, and bio marker test showed I would do better with gem/doce. I’ve just finished my second dose in the six week, once a week phase. Did you have significant abdominal bloating with your treatment? Mine was stronger with this second dose than the first and painful, wondering what to expect going forward. I have a call in to my doctor just to check. Hope you’re doing well and would be interested to hear how your journey has been going.

@deb2024
I have the same diagnosis. Had my TURBT on Sept 5, 2025 and have had 4 of the six weekly Gem/Doce treatments, which have been interrupted by two weeks between instillations 3 and 4 due to a UTI and has again been interrupted due to another UTI, so 5 will not take place for another couple of weeks. Oncologist says interruptions of a couple of weeks should not affect efficacy, but that's not what my AI source says! Whom to believe?? Anyone else had similar UTI experience and interrutions?
I've not had any problem with the instillations, once they used the correct catheter, and after-effects are urgency and nocturia. I have to get up about 6 times per night, which is a bit wearing.
The choice of Gem/Doce was based on the Vesta system biomarker analysis.